CHD7 and CHARGE syndrome: We detected a predominantly hypermethylation profile (Fig. 3A); the highest percentage of overlap in DMPs was with BAFopathies (11%, including ARID1A, ARID1B, SMARCB1, SMARCA2, SMARCA4), and CHARGE syndrome (10%, CHD7) (Fig. 3B and Supplementary Fig. 4).