LAMC3 and fibrosis: In this instance, single-cell spatial mapping analysis adds confidence to the results from the snRNAseq L–R analysis that BA with advanced fibrosis samples show potential interference with the communication pathway between these two cell types; specifically between LAMC3, a major component of basement membranes, and CD44, a cell surface receptor that has been implicated in fibrotic and wound healing processes19–21.