TMEM260 and heart disorder: Collectively, approximately 26% of Japanese patients with TA could be explained by the homozygous c.1617del variants in TMEM260, as the incidence of TA in Japan is estimated to be approximately 1/20,000 births, according to a survey of cardiac disease in childhood conducted by the Japanese Society of Pediatric Cardiology and Cardiac Surgery (https://jspccs.jp/wp-content/uploads/rare_disease_surveillance_2020.pdf).