LAG3 and neoplasm: Further flow-cytometric analysis of tumor-infiltrating CD8+ T cell exhaustion and activity markers revealed that overexpression of either mHKDC1WT or mHKDC1S600A could rescue PD-1 and LAG-3 expression suppressed by mHKDC1 KD (Fig. 2d), while decreasing the expression of activity markers (Fig. 2e).