In order to investigate whether the decreased exhaustion and increased activity of tumor-infiltrating T cells in HCC-bearing HKDC1 KO mice is caused by the effects of HKDC1 depletion specifically in tumor cells or immune cells, we examined the expression levels of HKDC1 in tumor cells and other cells in the liver from YAP5SA induced HCC-bearing mice. The gene discussed is HKDC1; the disease is neoplasm.