HKDC1 and neoplasm: We found that STAT1-Y701 phosphorylation was obviously decreased in IFNγ-stimulated HCC cells with HKDC1 knockdown compared to that in stimulated NTC controls (Fig. 3g and Supplementary Fig. 4f), as well as in YAP5SA-induced HCC-bearing HKDC1 KO mice relative to tumor-bearing WT mice (Supplementary Fig. 4g).