To explore this possibility, we examined the composition of tumor-infiltrating immune cell populations in YAP5SA-induced HCC mouse model of WT and HKDC1 KO mice, and our flow-cytometric results showed that the percentage of tumor-infiltrating PD1+ CD8+ T cells was significantly lower in HKDC1 KO mice than that in the WT group (Fig. 1b). This evidence concerns the gene HKDC1 and hepatocellular carcinoma.