DOK6 and Charcot-Marie-Tooth disease: Decreased α-tubulin acetylation and deficits in axonal transport are considered early characteristics of peripheral neuropathy,14 and increasing α-tubulin acetylation and salvage axonal transport defects may provide benefits in mice with Charcot-Marie-Tooth disease (CMT), the predominant type of inherited peripheral neuropathy.38 Notably, the human genetic and clinical data also strongly suggest that DOK6 is closely associated with peripheral neuropathy.