Axonal transport of protein and organelle cargoes is essential for the execution and maintenance of neuron functions.11–13 Remarkably, several mutations in motor proteins or motor regulator genes have been identified in associated with axonal forms of hereditary peripheral neuropathies.40,41 For example, mutations in DYNC1H1.42 or RAB7A.43 have been reported to cause CMT. This evidence concerns the gene RAB7A and Charcot-Marie-Tooth disease.