The single nucleotide polymorphisms of Dok6 found to increase susceptibility to Hirschsprung’s disease, which is most commonly associated with the RET genetic mutation, indicating the relevance of Dok6 to neurotrophic signaling.22 This supports the key role of Dok6 in maintaining axon function and its possible role in the pathogenesis of peripheral neuropathy. Here, DOK6 is linked to Hirschsprung disease.