After adjusting for potential confounders, we observed that a lipid profile with high TC levels (AOR 1.31, 95% CI [1.03, 1.68]), LDL levels (AOR 1.41, 95% CI [1.06, 1.88]), and Apo B levels (AOR 3.68, 95% CI [1.18, 11.53]) in early pregnancy was associated with an increased risk of CHD in offspring only among overweight/obese pregnant women (BMI ≥ 24 kg/m2). Here, APOB is linked to coronary artery disorder.