To further verify the effect of ibrutinib, we selected several ovarian cancer cell lines, and SKOV3 cells were shown to contain a relatively higher protein abundance of OTUD1 than OVCAR3 cells, accompanied by elevated protein levels of ASK1, p-ASK1, p-JNK and p-c-Jun (Fig. 7a). The gene discussed is MAPK8; the disease is ovarian cancer.