By exome sequencing and FISH approaches, we detected the most known NB recurrent alterations: the amplification of MYCN (n = 3.16%) [2], ATRX loss (n = 3.16%) [37], ALK point mutations (n = 2.11%) [5] and MDM2 amplification (n = 1.5%) [38]. Here, MDM2 is linked to neuroblastoma.