MTHFR and Rare hereditary thrombophilia: However, the prevalence of the three main inherited thrombophilia mutation (FVL, FII G20210A and MTHFR C677T) among healthy Palestinians and healthy populations in other regions of the world (Europe and America) [45] revealed that FVL and MTHFR C677T prevalence ranked Palestine among countries with high prevalence of these mutations, but FII G20210A prevalence was consistent with other regions as shown in Table 5 [45].