MTHFR and Rare hereditary thrombophilia: Statistical analysis of the main eight thrombophilia mutations analyzed in this study, revealed that only the proportion of mutant MTHFR (A1298C) (heterozygotes and mutant homozygote) has a significant difference between patients and controls (p = 0.016), with a prevalence of 64% among patients (48% heterozygous and 16% homozygous) and 47% among controls (37% heterozygous and 10% homozygous) (Table 1).