Also, most studies that tackled the role of inherited thrombophilia in RM have focused on a small group of mutations [3, 10, 11, 17, 24, 26, 29], namely FVL, FII G20210A, MTHFR C677T and A1298C, while studies that investigated a larger panel of thrombogenic mutations are rare [15]. This evidence concerns the gene F5 and thrombophilia.