In contrary, the other inherited thrombophilia mutations analyzed in this study (FVL, FII G20210A, and MTHFR C677T, BFG − 455G > A, PAI1 5G/4G, FXIIIA V34L, FV HR2) displayed no significant association with unexplained RM. The gene discussed is SERPINE1; the disease is Rare hereditary thrombophilia.