In vivo research on MS is commonly performed in an animal model called experimental autoimmune encephalomyelitis (EAE), in which inflammation of the CNS is induced via the administration of an adjuvant and a CNS antigen (e.g., myelin–oligodendrocyte glycoprotein (MOG), myelin proteolipid protein (PLP), or myelin basic protein (MBP)) or myelin-reactive T cells [119]. This evidence concerns the gene PLP1 and myeloid sarcoma.