In vivo research on MS is commonly performed in an animal model called experimental autoimmune encephalomyelitis (EAE), in which inflammation of the CNS is induced via the administration of an adjuvant and a CNS antigen (e.g., myelin–oligodendrocyte glycoprotein (MOG), myelin proteolipid protein (PLP), or myelin basic protein (MBP)) or myelin-reactive T cells [119]. The gene discussed is PLP1; the disease is experimental autoimmune encephalomyelitis.