Interestingly, the increased migration of CD56bright NK cells is irrespective of the disease status: no differences were found between CD56bright NK cells derived from healthy donors or MS patients [61], although peripheral CD56bright NK cells in MS patients express higher levels of the CAMs CD49d (subunit of VLA-4) and CD31 compared to controls (Fig. 5) [4]. Here, ITGA4 is linked to myeloid sarcoma.