Using a defined cut-off, hs-CRP > 0.35 mg/dL, which was the cut-off level in the QMH immunology laboratory to define normal hs-CRP value, had significantly higher risk to develop any bronchiectasis exacerbation with OR of 4.222 (95% CI = 1.700–4.885, p = 0.002) and aOR of 3.915 (95% CI = 1.423–10.771, p = 0.008). This evidence concerns the gene CRP and bronchiectasis.