Studies have shown CSF proteome changes similar to Alzheimer's disease during chemotherapy, including increases in Apolipoprotein E (APOE) and Calsyntenin-1 (CLSTN1) [67–69], and decreases in Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3), linked to several neurological disorders [70–75]. This evidence concerns the gene APOE and nervous system disorder.