IGSF8 and brain neoplasm: This group included Neuromodulin (GAP43) involved in nerve growth, Gamma-enolase (ENO2) promoting neuron survival (which has been known to increase in brain tumor patients [51, 52]), Prosaposin receptor GPR37 (GPR37) and Prostaglandin-H2 D-isomerase (PTGDS) with anti-apoptopic effects oligodendrocytes [53–56], and Immunoglobulin superfamily member 8 (IGSF8) involved in neurite outgrowth and maintenance [57].