SCNN1G and ulcerative colitis: Five genes were downregulated quite strongly in challenged colon organoids: SLC16A9, SLC6A5, SCNN1G, SLC26A4, and SLC43A2. SLC16A9 (MCT9), a proton-linked monocarboxylate transporter, was reported to be downregulated in ulcerative colitis [33].