Conversely, when OLFM2 is knocked down in cells SW480 and SW620, there is an increase in E-cadherin expression and a decrease in N-cadherin and Vimentin expression (Fig. 9B and C).These findings indicate that OLFM2 plays an important role in promoting EMT in colon cancer cells. Here, OLFM2 is linked to malignant colon neoplasm.