CARD8 and Atherosclerotic lesion: We have also identified that CARD8 acts as a regulator of inflammatory cytokines and chemokines like CXCL1, CXCL6, PDGF-A, MCP-1 and IL-6 in endothelial cells and atherosclerotic lesions [3], which indicates that CARD8 plays an important role for the regulation of proteins involved in inflammation.