These variants were detected by genome sequencing (27.2%), exome sequencing (52.4%) or both (20.4%) in a previous study (Fig. 8C), and 40.9% of them will cause loss of function (nonsynonymous, splicing and frameshift) (Fig. 8D) that MUC19 was assessed to have high association with Parkinson’s disease by M-GBBD is sensible, as supported by GWAS results. This evidence concerns the gene MUC19 and Parkinson disease.