In the DisGeNET database, LRP6, F11, CXCL10, TCF4 and IGF2 are identified as the top five genes associated with Alzheimer's disease, with association scores of 0.989, 0.981, 0.953, 0.938 and 0.914, respectively (Fig. 7A). Here, TCF4 is linked to early-onset autosomal dominant Alzheimer disease.