CNR1 and colorectal cancer: Cannabinoid receptors (CB), including CB1 and CB2, play important roles in various physiological processes, including memory, pain sensation, and movement.[9] Mounting evidence suggests activation of cannabinoid receptors is associated with inhibition of tumorigenesis and progress in multiple tumor models.[10, 11, 12] For example, CB1 activation by the selective agonist arachidonoyl 2′‐chloroethylamide (ACEA) could suppress the proliferation, migration, and invasion of colorectal cancer cells.