As regards the role of miR-1202 in T21-dependent myeloproliferative disorders, data from TAM and myeloid leukaemia patients provided substantial support to our findings by showing that miR-1202 down-modulation at diagnosis is accompanied by elevated GATA-1 levels, with more marked effects on GATA-1S. Here, GATA1 is linked to myeloid leukemia.