In the light of these findings, although further research is required to clarify the processes regulating the expression of GATA-1 and its isoforms, we might thus speculate that miR-1202 down-modulation could promote PRMT1 activity, thus stimulating alternative splicing processes and pushing toward the production of the pro-leukaemia isoform GATA-1S (figure 9). This evidence concerns the gene PRMT1 and leukemia.