Clonal GATA-1 mutations reported in TAM include small insertions/deletions or point mutations clustered in exon 2 or at the beginning of exon 3 and prevent the translation of full-length GATA-1 thus resulting in exclusive production of GATA-1S leading to thrombocytopenia and excess blasts (TAM blasts) in the peripheral blood [21,24]. The gene discussed is GATA1; the disease is Thrombocytopenia.