Subsequently, we analyzed the differences in NUDT21 mRNA expression levels between pan-cancer and corresponding normal tissues; NUDT21 gene was significantly changed in 16 tumor types, including significant upregulation of expression in CHOL, COAD, ESCA, HNSC, LIHC, LUSC and STAD, while in BRCA, GBM, KICH, KIRC, KIRP, PAAD, SKCUM, THCA, and UCEC were down-regulated in expression (Figure 2B). Here, NUDT21 is linked to cancer.