The combined results showed that NUDT21 was extremely expressed and had a poor prognosis in LUAD, PAAD, HNSC and THCA, while it had a better prognosis in CHOL, COAD, GBM, and KIRC, demonstrating the heterogeneity of NUDT21 expression in different tumor type. The gene discussed is NUDT21; the disease is glioblastoma.