In addition, we analyzed the NUDT21 and chemokine, receptor, and immune activator relationships, as shown in the heat map (Supplementary Figure 1E), NUDT21 was negatively correlated with several chemokines (CCL1, 2, 3, 4, and 5), numerous receptors, and immunostimulatory agents in pan-cancer. The gene discussed is NUDT21; the disease is cancer.