Although traditional apoptosis is not immunogenic, several researches have shown that in certain conditions under Caspase deficiency, immunogenic apoptosis can absolutely be induced through activation of NF-κB signaling pathway [29] and cGAS/STING pathway [30] to trigger adaptive antitumor or antiviral immune responses. This evidence concerns the gene CGAS and hyperinsulinemic hypoglycemia, familial, 4.