It has been reported that caspase-1-dependent pyroptosis in macrophages is associated with the secretion of inflammatory factors IL-1β and IL-18.52 Besides, caspase-1-deficient mice can resist endotoxic shock caused by large doses of LPS.53 We also observed that AM pyroptosis participated in the LPS-induced ALI. The gene discussed is CASP1; the disease is acute respiratory distress syndrome.