The histopathologic manifestations of LPS-induced ALI mice model included diffuse alveolar injury, lung tissue structure destruction, alveolar septal thickening, inflammatory cell infiltration, a little pink fibrinous deposit, increased levels of IL-1β and IL-18 in serum and bronchoalveolar lavage fluid (BALF), and increased secretion of LDH and total protein in BALF (P < .05) (Fig. 1A–1H). This evidence concerns the gene IL18 and acute respiratory distress syndrome.