We observed a low or anticorrelation between gene expression signatures and phenomena such as MYC activation (11), proliferation (28, 43), and colorectal cancer subtypes or cell-of-origin (e.g., goblet-like, crypt, or CIN) gene expression signatures (refs. 2, 3, 44; Supplementary Fig. S5). This evidence concerns the gene MYC and colorectal cancer.