When GnRH analogues result into suppression of serum T levels, the most likely etiologies, in order of frequency, were OHT, a gonadotrophin-responsive ovarian tumor, or very rarely, an androgen-secreting adrenal adenoma or macronodular adrenal disease with aberrant response to gonadotrophins. Here, GNRH1 is linked to adrenal cortex adenoma.