While this surgical procedure restored normonandrogenemia in a patient with a final diagnosis of bilateral macronodular adrenocortical disease, without apparent relapse after 59 months of follow-up, clinical and biochemical hyperandrogenism persisted in that presenting with an androgen-secreting adrenal adenoma showing aberrant LH/hCG receptors. The gene discussed is PLOD1; the disease is hyperandrogenism.