The eight cases with ACTH-dependent functional hyperandrogenism are on active surveillance and were treated with dermo-cosmetic measures (four cases), oral low-dose prednisone treatment (one case), glucagon-like peptide 1 receptor agonists (one case), bariatric surgery (one case), or spironolactone (one case). The gene discussed is GLP1R; the disease is hyperandrogenism.