Additionally, FBP1's binding to the WW domain of IQ motif containing GTPase-activating protein 1 (IQGAP1) blocks IQGAP1-dependent ERK1/2 phosphorylation, leading to an enhanced anticancer response to gemcitabine in pancreatic ductal adenocarcinoma [16]. This evidence concerns the gene IQGAP1 and pancreatic ductal adenocarcinoma.