Some common pathways were shared in NR patients compared to R patients across three cancer types, including immune-related pathways such as Th17 cell differentiation, the IL-17 signal pathway, and the HIF-1 signal pathway, as well as tumor, infection, autoimmune disease-related pathways such as the JAK-STAT signal pathway and cell adhesion pathways (Fig. 2D–F). The gene discussed is IL17A; the disease is infection.