In the jejunum and colon, the levels of the IL-6, IL-8, TNF-α, and IFN-α were significantly higher in PDCoV HNZK-02-P5- and HNZK-02-P150-inoculated piglets than in the control group, and the PDCoV HNZK-02-P150 infection induced higher levels of TNF-α (P < 0.05) and IFN-α (P < 0.01) than those in the PDCoV HNZK-02-P5 infection (P < 0.05). Here, CXCL8 is linked to infection.