In this study, the infection of PDCoV HNZK-02-P5 promoted CCK level and decreased GLP-1 levels in serum, and inhibited short-term feed intake in piglets, which resulted that the body weight in PDCoV HNZK-02-P5 inoculation group was decreased, but the HNZK-02-P150-inoculated piglets remained relatively stable. Here, GCG is linked to infection.