Tumor necrosis factor (TNF)‐α/TNF receptor superfamily member 1B (TNFR2) was used to identify a new population of Tregs, TNF‐α/TNFR2 pathway can increase Foxp3 levels and latent TGF‐βproduction, The level of TNFR2+ Tregs in GC patients was closely correlated with both the TNM stage and N stage. Here, TNFRSF1B is linked to gastric cancer.