For instance, TAM derived cytokines, such as IL‐6, IL‐1β, IL‐8, TNF‐α, CCL‐17, and CCL‐22 significantly contribute to proliferation of GC cells, immunosuppression and angiogenesis in TME through the mediation of immune surveillance which support tumor growth and metastasis as a result.3 Here, TNF is linked to neoplasm.