POLR3A and Wolcott-Rallison syndrome: In this study, we report two Omani and one Saudi Arabia consanguineous families with WRS in an autosomal recessive pattern of inheritance, associated with homozygous POLR3A gene variants, (NM_007055: c.2456C>T; p. Pro819Leu and c.1895G>T; p Cys632Phe) previously described to cause WRS phenotypes (Moon et al., 2023; Paolacci et al., 2017; Wambach et al., 2018; Wiedemann, 1979).