POLR3A and Wolcott-Rallison syndrome: Bi‐allelic variants in POLR3A have been associated with phenotypes distinct from WRS: hypogonadism, hypomyelinating leukodystrophy, and hypogonadotropic with or without oligodontia (Paolacci et al., 2017; Wambach et al., 2018; Wiedemann, 1979).