Previous studies have indicated a significant increase in the length of primary cilia in the hippocampus of APP/PS1 compared to controls, and intraperitoneal administration of 5‐hydroxytryptamine receptor subtype 6 (5‐HT6) antagonist SB271046 effectively reduced cilia length and rescued cognitive impairment in APP/PS1 mice.[28] Among these, DNALI1, an essential component of the ciliated dynamic arm,[29] emerged as the key gene in our analysis, primarily responsible for cilium movement. The gene discussed is DNALI1; the disease is Cognitive impairment.