The AMD associated loci are within the genes CFH, ARMS2, HTRA1, C2, CFB, C3, CFI, C9 and others (Klein et al., 2005; Maller et al., 2006; Maller et al., 2007; Fagerness et al., 2009; Neale et al., 2010; Raychaudhuri et al., 2011; Fritsche et al., 2013; Seddon et al., 2013; Zhan et al., 2013; Yu et al., 2014; Fritsche et al., 2016; Yu et al., 2016) in the immune, inflammatory, lipid, angiogenesis and DNA and cell repair pathways. This evidence concerns the gene CFI and age-related macular degeneration.