To determine whether the association of rs28357075 (V1207A) with AMD was independent of the C4A copy number variation, we performed conditional analysis including a proxy SNP of rs429608 (i.e., rs641153 missense variants in CFB, D′ = 0.96 and r2 = 0.67) in the logistic regression model. This evidence concerns the gene CFB and age-related macular degeneration.