CFH R1210C was also associated with earlier age of onset of AMD, more rapid progression to advanced stages, and a typical fundus phenotypic appearance including high drusen burden in the macula and extramacular locations in both eyes (Seddon et al., 2014; Ferrara and Seddon, 2015; Seddon and Rosner, 2019; Seddon et al., 2020). The gene discussed is CFH; the disease is age-related macular degeneration.