Figures 2A, B show forest plots of the two C4 variants in ARTS, MMAP and UKBB. The change of Rodgers-1 related residue to Chido-1 (V1207A) in C4A increased the risk of AMD. The other C4A variant, (P1120T, rs201206908), was protective in the combined discovery cohorts (OR = 0.26, p = 3.9 × 10−4), but was not significantly associated with AMD in the UKBB cohort (OR = 0.90, p = 0.55). The gene discussed is C4A; the disease is age-related macular degeneration.