Several common and rare genetic variants in complement genes have been reported to be associated with AMD, including CFH, C2, C3, CFB, CFI and C9 (Klein et al., 2005; Maller et al., 2006; Maller et al., 2007; Fagerness et al., 2009; Neale et al., 2010; Raychaudhuri et al., 2011; Fritsche et al., 2013; Seddon et al., 2013; Zhan et al., 2013; Yu et al., 2014; Fritsche et al., 2016; Yu et al., 2016). The gene discussed is CFB; the disease is age-related macular degeneration.