Notably, DNA/RNA-binding proteins like fused in sarcoma/translated in liposarcoma (FUS/TLS) and TAR DNA-binding protein (TDP)-43 have been pinpointed as the primary etiological factors in the familial forms of the neurodegenerative condition of ALS (Zhang et al., 2014). Here, TARDBP is linked to amyotrophic lateral sclerosis.