GPX4 and obesity due to melanocortin 4 receptor deficiency: A large number of genetic epidemiological studies have linked gpx4 variants and GPx4 content/activity with obesity (Rupérez et al., 2014; Costa-Urrutia et al., 2020) cardiovascular and inflammatory diseases (Polonikov et al., 2012; Berdaweel et al., 2022), and cancer (Méplan et al., 2010).