As the only member of the glutathione peroxidase superfamily capable of neutralizing lipid peroxides, glutathione peroxidase-4 (GPx4) is a master regulator of ferroptosis and experimental studies have shown that this selenoenzyme has important pathophysiological roles in many cardiometabolic, neurodegenerative, autoimmune diseases and malignancies (Park et al., 2019; Ursini et al., 2022; Wang et al., 2022; Xu et al., 2022). This evidence concerns the gene GPX4 and autoimmune disease.