C3G intervention in animals significantly downregulates the level of ROS in the pancreas of diabetic db/db mice, upregulates the activities of superoxide dismutase (SOD) and catalase (CAT), alleviates the islet OS induced by hyperglycemia in diabetic mice, and ameliorates T2DM (Ye X. et al., 2021). This evidence concerns the gene CAT and type 2 diabetes mellitus.