In vivo experiments demonstrated that knockdown of ZNF143 or lncRNA NEAT1 significantly upregulated hepatic PINK1, Parkin, Beclin1, and LC3II/I expression in high-fat diet-induced NAFLD mice, further validating the ameliorative role of the ZNF143/lncRNA NEAT1/ROCK2 signaling pathway in high-fat diet-induced hepatic tissue injury in mice (Dong et al., 2023). The gene discussed is PINK1; the disease is metabolic dysfunction-associated steatotic liver disease.