In vivo experiments showed that overexpression of PINK1 reduced the mean cross-sectional area of cardiomyocytes in mice with transverse aortic constriction (TAC)-induced myocardial injury, downregulated the levels of atrial natriuretic peptide (ANP), β-MHC, Col I, transforming growth factor-β1 (TGF-β1), and p62 protein levels, upregulated Beclin1 and LC3 protein expression, promoted myocardial mitophagy, and ameliorated cardiac hypertrophy and fibrosis in TAC mice (Ma Z. et al., 2023). The gene discussed is NPPA; the disease is cardiac hypertrophy.