CP can significantly upregulate the protein expression of PGC-1α, PPARα, PINK1, Parkin, ATG7, and LC3I/II in the liver of high-fat dilated-induced NAFLD rats, downregulate that of P62, activate mitophagy mediated by PINK1/Parkin, and block liver steatosis induced by high-fat diet in rats. Here, PPARGC1A is linked to metabolic dysfunction-associated steatotic liver disease.