Ginsenoside Rg3 significantly increased the expression of ULK1 and FUNDC1 in heart failure (HF) rats’ hearts, promoted the interaction of FUNDC1 and LC3 to initiate mitophagy, reduced the number of inflammatory cell infiltration, infarct size, and serum biomarker expression in HF rats’ hearts, and significantly decreased the mRNA expression of natural peptide predictor a (NPPA), NPPB, and the protein levels of ColI and ColII. This evidence concerns the gene MAP1LC3A and hydrops fetalis.