Aerobic exercise for 4 weeks significantly upregulated the expression of FUNDC1 in coronary artery tissues of LAD-induced aging MI/R-injured mice and downregulated the expression of IL-6, IL-8, TNF-α, VCAM-1, E-selectin, and ICAM-1 in left ventricular tissues, which significantly enhanced myocardial glucose uptake, inhibited inflammatory response and neutrophil migration, and attenuated cardiac injury. Here, FUNDC1 is linked to myocardial infarction.