Six-week intraperitoneal injection of SPD and resistance training increase the p-AMPKα/AMPKα ratio and FOXO3a protein expression in skeletal muscle of D-galactose (D-gal)-induce senescent muscular dystrophy rats, activate the AMPK-FOXO3a signaling pathway, upregulate the levels of Beclin1 protein and the LC3-II/LC3-I ratio, and downregulate those of the p62 protein. Here, FOXO3 is linked to muscular dystrophy.