MAP1LC3A and cardiac hypertrophy: In vivo experiments showed that overexpression of PINK1 reduced the mean cross-sectional area of cardiomyocytes in mice with transverse aortic constriction (TAC)-induced myocardial injury, downregulated the levels of atrial natriuretic peptide (ANP), β-MHC, Col I, transforming growth factor-β1 (TGF-β1), and p62 protein levels, upregulated Beclin1 and LC3 protein expression, promoted myocardial mitophagy, and ameliorated cardiac hypertrophy and fibrosis in TAC mice (Ma Z. et al., 2023).