Inhibition of Parkin- and PTEN-induced putative kinase 1 (PINK1)-mediated mitophagy exacerbates hepatic lipogenesis, inflammation, and insulin resistance in NAFLD mice, and upregulation of mitophagy levels effectively ameliorates hepatic steatosis in NAFLD mice (Chen et al., 2023). The gene discussed is PRKN; the disease is Insulin resistance.