This axis facilitates cell signaling pathways such as PI3K/AKT, NF-kB, ERK/MEK, and HIF-a, leading to uncontrolled proliferation and immortality of tumor cells.42Simultaneously, these signaling pathways regulate MMPs, growth factors, and inflammatory factors, thus removing obstacles for tumor invasion and metastasis. The gene discussed is NFKB1; the disease is neoplasm.