The composition of IL-2R, a functional receptor, consists of three crucial constituents: IL2Rα, which is alternatively referred to as CD25 and serves as the α chain; IL2Rβ, also known as CD122, functioning as the β chain; and IL2Rγ, known as CD132, acting as the γ chain.33In humans, the expression of IL2Rα demonstrates significant elevation in a diverse array of hematological malignancies, while its presence is limited to only a handful of solid tumor types. Here, IL2RG is linked to hematologic disorder.