Current approved treatments are limited and focus only on restoration of cerebral blood flow to the ischemic area of the brain, achieved by either intravenous administration of tissue plasminogen factor (tPA) to dissolve blood clots and/or endovascular mechanical thrombectomy to remove a large vessel blood clot causing ischemia (National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group, 1995). The gene discussed is PLAT; the disease is Stroke.