The combination of wild-type homozygous genotype for MC2R (AA) and variant homozygous genotype for GLCCI1 (TT), risk genotypes for the respective genes, showed a stronger association with ALL if compared to the individual effect of each variant (OR = 2.61; 95% CI = 1.16–5.87). This evidence concerns the gene MC2R and acute lymphoblastic leukemia.