Alzheimer’s disease is the most common form of dementia (Gabandé-Rodríguez et al., 2020), characterized by the pathological hallmarks of extracellular deposition of amyloid-β (Aβ) plaques resulting from impairment of Aβ clearance from the CNS (Mawuenyega et al., 2010), and intraneuronal hyperphosphorylated tau protein tangles (Johnson and Stoothoff, 2004). The gene discussed is MAPT; the disease is Alzheimer disease.