Increased TSPO levels are positively correlated with Aβ accumulation (Parbo et al., 2017; Dani et al., 2018; Zou et al., 2020) and tau aggregation (Dani et al., 2018) in mild cognitive impairment (MCI) and AD, supporting a role for microglia activation and neuroinflammation in AD. Here, MAPT is linked to Alzheimer disease.