CD8A and Alzheimer disease: • Upregulated by microglia in AD (Francistiová et al., 2020) and modulates chemokine production associated with CD8 + T cell recruitment in Aβ pathology• (Martin et al., 2019)Testing of a novel P2RX7 PET tracer ([11C]SMW139) in human post-mortem brain tissue demonstrated no differences in binding between AD and control tissue (Janssen et al., 2018).