Adipose tissue can release molecules (adipokines) that regulate lipid metabolism, interact with insulin sensitivity, and may contribute to inducing fibrogenesis in the liver (18); in addition, adipose tissue, especially visceral adipose tissue, comprises multiple cell populations that produce adipokines and insulin-like growth factor, plus macrophages and other immune cells that stimulate the development of lipotoxic liver disease (19). The gene discussed is INS; the disease is liver disorder.