ANXA7 and breast carcinoma: To investigate whether ANXA7 participates in lysosome repair, we treated MCF7 breast carcinoma cells and HeLa cervix carcinoma cells with L-Leucyl-L-Leucine O-methyl ester (LLOMe), a lysosomotropic agent which enters cells via receptor-mediated endocytosis and is converted to a membranolytic compound specifically in the endolysosomal compartments (Thiele and Lipsky, 1990).