In the RAS mutant NSCLC mouse model, the novel CD73 antibody Ab001/Ab002 and the humanized antibody Hu001/Hu002 were found to effectively regulate the TME, reduce the infiltration level of M2 tumor-associated macrophages and MDSCs, induce the accumulation of mature DCs, promote effector T cells (Teff) proliferation and interferon γ (IFN-γ) secretion, enhance T-cell-mediated cytotoxicity, and ultimately inhibit tumor growth in mice (29). Here, NT5E is linked to non-small cell lung carcinoma.