Similarly, researchers found that there were a large number of activated and clonally expanded CD4+ and CD8+ T cells infiltrating the myocardium, cardiac conduction system and tumor tissue of patients with myocarditis caused by ICI treatment, suggesting that both cardiomyocytes and tumors express antigens can be recognized by monoclonal T cells (13, 41, 42). This evidence concerns the gene CD8A and neoplasm.