Interestingly, we found that the “EPITHELIAL_MESENCHYMAL_TRANSITION” gene set, which is closely related to tumor invasion and proliferation (25), was more enriched in GBM than LGG, and TRIM56 was more strongly associated with tumor proliferation and invasion-related pathways in GBM (Supplementary Figures 1A, B). Here, TRIM56 is linked to neoplasm.