Then we used R package “Cellchat” to evaluate the cellular communication patterns of the two tumor subsets to other cells in the tumor microenvironment (27), and found that compared with TRIM56 low expression subset, TRIM56 high expression subset could act on macrophages/microglia and endothelial cells by overexpressing secreted proteins MIF and VEGF respectively (Figure 7F). This evidence concerns the gene VEGFA and neoplasm.