The HSP-tumor antigen complex can be effectively recognized by APCs, promoting their maturation (12), In our study, we found that the number of monocytes in peripheral blood of recurrent HCC patients significantly increased after the RFA, and culturing PBMC with post-RFA serum didn’t directly increase the population of monocytes, these findings suggest that RFA could enhance the recruitment of monocytes from the lymphatic organs. This evidence concerns the gene LINC01194 and hepatocellular carcinoma.