SPP1 and pulmonary emphysema: A role of MoAM in tissue remodeling was further supported by their increased expression of tissue remodeling associated markers (Spp1, Pdgfa, Arg1, Fn1, Tgfb1, Plaur, Pdpn) including several genes encoding for metalloproteinases that are associated with extracellular matrix (ECM) degradation and emphysema such as Mmp8, Mmp14, Mmp19, Mmp12 (Figures 5A, D, G).