The co-existing variants in genes other than NOD2 might have an impact on disease phenotype in 4 patients with YAOS with features of mAIDs [TNFRSF11A-associated hereditary fever disease - TRAPS11 (36–38), n=2 and/or FMF, n=3] (Supplementary Table 2). The gene discussed is NOD2; the disease is Yao syndrome.