NOD2 and Blau syndrome: It is linked to specific NOD2 sequence variants, which are distinct from those described in Blau syndrome and early onset sarcoidosis, representing the familial and sporadic forms of the same pediatric noncaseating granulomatous SAID, respectively (7, 8), but also in multifactorial Crohn’s disease (9); on the other hand, there is also evidence supporting the presence of shared variants among these nosological entities.