Another patient (no. 11 in Supplementary Table 2) had two rare variants in the TNFRSF11A gene as well as a variant in PSMB8. Clinical features included fever episodes lasting up to 10 days, pericarditis, abdominal pain, splenomegaly, partial response to non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine, albeit good response to steroids. The gene discussed is TNFRSF11A; the disease is Splenomegaly.