A similar investigation also revealed EGCG suppressed ACC protein expression in hepatoma cells and proposed the potential mechanism of anti-DNL should be attributed to EGCG’s suppression on the receptor tyrosine kinases (RTKs), which mediate PI3K/Akt/mTOR complex 1 (mTORC1)/sterol regulatory element-binding protein 1 (SREBP1) axis (212). This evidence concerns the gene AKT1 and hepatocellular carcinoma.