For example, in solid tumors, EGCG has been found to prevent tumor growth and proliferation by reducing the activation of molecules such as mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinase (ERK), and protein kinase B (Akt), to induce cell cycle arrest by upregulating p21 transcription, to trigger mitochondrial cytochrome C-mediated apoptosis by diminishing Bcl-2 and Bcl-xL expression, and to attenuate malignant migration and invasion by reducing the levels of matrix metalloproteinases (MMPs) (16, 17, 19). Here, AKT1 is linked to neoplasm.