TAMs can induce the generation of a repertoire of mediators, including various growth factors, cytokines, and chemokines, multiple anti-apoptotic factors mediated by NF-κB, and abundant soluble immunosuppressive factors involved in IL−10, TGF-β, ARG1, IDO, and PD-L1, to reshape the TIME in favor of tumor progression and subvert local immune surveillance (84). This evidence concerns the gene TGFB1 and neoplasm.