CD274 and neoplasm: An EGCG-delivery responsive penetrating nanogels based on a nano-sized controlled releasing system of the soluble cyclodextrin-drug inclusion complex was also found to decrease the PD-L1 expression in tumor cells, promote DC maturation, stimulate CTL infiltration and activation, and attenuate the suppression effects from Tregs, thereby switching “cold” tumor to “hot” tumor (255).