CD274 and neoplasm: It was reported that a phenolic-based tumor-permeated nano-framework composed of EGCG and phenylboronic acid-modified platinum nanoparticles could not only downregulate PD-L1 expression but effectively promote the maturation of DCs and facilitate the infiltration of CTLs, thus amplifying immunotherapy outcomes and generating a powerful antitumor immune response in terms of the suppression of primary tumor and metastasis (254).