Analogously, in comparison to EGCG alone, combined administration of EGCG and curcumin better attenuated the evolution of normal ECs to TECs stimulated by tumor medium supernatant or tumor tissue homogenate through inhibiting the JAK/STAT3/IL-8 pathway, thereby reversing endothelial angiogenesis (147). The gene discussed is CXCL8; the disease is neoplasm.