Katzke et al. [20] performed a case-cohort study on the prospective European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort (n = 1,632) and reported a significant association between high AST/ALT ratios and risk of prostate cancer (HR: 1.61, 95% CI, 1.10-2.36), all-cause mortality (HR: 1.60, 95% CI, 1.25-2.04), and cancer mortality (HR: 1.67, 95% CI, 1.26-2.23). This evidence concerns the gene GPT and Familial prostate cancer.