The multivariate-adjusted HRs were adjusted for gender, age, obesity, alcohol drinking habits, smoking habits, history of cardiovascular disease, hypertension, hypertriglyceridemia, low HDL-cholesterolemia, hyper LDL-cholesterolemia, diabetes, chronic kidney disease, hyperuricemia, and elevated gamma-glutamyl transpeptidase. The gene discussed is GGTLC1; the disease is chronic kidney disease.