GPT and cancer: Furthermore, in a retrospective analysis involving 85,658 patients at a Japanese hospital, categorized based on their alcohol consumption, men who were regular drinkers exhibited elevated adjusted HR for all types of cancer in the very high (adjusted HR 1.36; 95% CI 1.13-1.63) and high (adjusted HR 1.26; 95% CI 1.05-1.50) AST/ALT ratio groups [22].