For example, one study separated TAM into seven TAM subsets in tumor tissues, including inhibin beta A chain (INHBA)+ TAMs, complement C1q subcomponent subunit C (C1QC)+ TAMs, ubiquitin like protein ISG15 (ISG15)+ TAMs, NACHT, LRR and PYD domains containing protein 3 (NLRP3)+ TAMs, LYVE1+ TAMs, and sphingosine- 1-phosphate phosphatase 1 (SPP1)+ TAMs (74). This evidence concerns the gene ISG15 and neoplasm.