To gain insights into how exTregs may convert into TH17 cells, following CH, we first explored the Gene Ontology (GO) pathways that were enriched within the CD4+ memory T-cell cluster when comparing CH to normoxia, finding the most abundantly enriched GO terms to be associated with DNA transcription, translation, and regulation; chromatin and protein modification; and apoptosis (Figure 7A). The gene discussed is CD4; the disease is cyclic hematopoiesis.