IL10 and periodontitis: Widespread expression of the M2 macrophage’s IL-10 in inflamed periodontal tissue is linked to tissue healing, a reduction in periodontitis severity, and a reduction to inflammation (Lappin, MacLeod, Kerr, Mitchell and Kinane, 2001; Garlet, Martins, Fonseca, Ferreira and Silva, 2004; Garlet, 2010).