In co-cultured murine neuroblastoma and microphage cell lines (Neuro-2A and RAW264.7) that mirror the inflammatory infiltrate of CIPN, we evaluated the effect of PS on the expression of four cytokines, IL-6, IL10, CXCL-1, and CXCL-2, all involved in CIPN (Brandolini et al., 2019). This evidence concerns the gene CXCL1 and neuroblastoma.